Available for Android and iOS devices. For more information, ask your healthcare provider or pharmacist. The same is true of niacin, which raises HDL but is unsafe when taken with a statin. Is new cholesterol-lowering medication Nexletol a solution for those who can’t take statins? https://www.webmd.com/drugs/2/drug-178906/nexletol-oral/details You and your healthcare provider should decide if you will take Nexletol or breastfeed. Microsoft may earn an Affiliate Commission if you purchase something through recommended links in this article. Following a careful diet, exercising regularly, and dealing … Taking simvastatin or pravastatin with Nexletol may increase your risk of developing muscle pain or weakness (myopathy). Do not throw away the packet that helps to keep your medicine dry (desiccant). symptoms of the common cold, flu, or flu-like symptoms, Store Nexletol in the original package at room temperature between 68ºF to 77ºF (20ºC to. NEXLETOL was associated with an increased risk of benign prostatic hyperplasia (BPH) or prostatomegaly in men with no reported history of BPH, occurring in 1.3% of NEXLETOL-treated … Keep Nexletol and all medicines out of the reach of children. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. harmed people even though it raised HDL levels. Stop taking Nexletol immediately and get medical help right away if you get any of the following signs or symptoms of a tendon rupture: hear or feel a snap or pop in a tendon area, bruising right after an injury in a tendon area, unable to move the affected area or put weight on the affected area. Last month, a new kind of medication called bempedoic acid (Nexletol) was approved for use by the FDA as a novel way to lower cholesterol. Tendon rupture can happen while you are taking Nexletol. Like us on Facebook to see similar stories, Colorado Gov. Visit The Philadelphia Inquirer at www.inquirer.com. Bempedoic acid, sold under the brand name Nexletol among others, is a medication for the treatment of hypercholesterolemia (high blood cholesterol levels). It is not known if Nexletol is safe and effective in people with severe liver problems. Do not use Nexletol for a condition for which it was not prescribed. We comply with the HONcode standard for trustworthy health information -, Drug class: miscellaneous antihyperlipidemic agents. It is not known if NEXLETOL is safe and effective in people with severe kidney problems including people with end-stage kidney disease who are on dialysis. Nexletol (bempedoic acid) is an adenosine triphosphate-citrate lyase inhibitor used as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.. What Are Side Effects of Nexletol? But despite these advances, many patients still have problems tolerating statins. The injectable drugs work but and are prohibitively expensive for many. The risk of getting tendon problems while you take Nexletol is higher if you: are taking antibiotics (fluoroquinolones). Most people with high cholesterol need a drug called a statin, which includes the popular drugs called atorvastatin (Lipitor) and rosuvastatin (Crestor). We have learned that lowering LDL cholesterol (so-called bad cholesterol) to levels that were previously thought to be too low is both safe and effective. are breastfeeding or plan to breastfeed. Does this new medication add something special? The development of another medication to help patients who cannot take a statin would help fight heart disease. Nexletol may cause serious side effects, including: The most common side effects of Nexletol include: Tell your healthcare provider if you have any side effect that bothers you or that does not go away. Talk to your healthcare provider about the risk of tendon rupture with continued use of Nexletol. Nexletol can cause simvastatin and pravastatin to build up in your blood, raising your risk for this side effect. By David Becker, For The Inquirer, The Philadelphia Inquirer. It is not known if NEXLETOL is … The prescription alternatives for those who cannot tolerate a statin include Zetia (ezetimibe) — which works by preventing cholesterol absorption from the intestine — and the injectable, expensive PCSK-9 inhibitors (Repatha and Praluent). It is not known if Nexletol passes into your breast milk. David Becker is a frequent Inquirer contributor and a board-certified cardiologist with Chestnut Hill Temple Cardiology in Flourtown, Pa. [1] [2] Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate citrate lyase, which is involved in making cholesterol. Do not give Nexletol to other people, even if they have the same symptoms that you have. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Check with your healthcare provider or pharmacist if you are not sure. Medically reviewed by Judith Stewart, BPharm. Limitations of Use The effect of Nexletol on cardiovascular morbidity and mortality has not been determined. Nexletol is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C. heterozygous familial hypercholesterolemia (HeFH). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. You should not do both. There has been minimal muscle aching reported.It is priced at about $300 a month.I doubt bempedoic acid will be the drug to help the majority of people who cannot take statins. General information about the safe and effective use of Nexletol. It has not caught on for several reasons, mainly because of a lack of consistency among poorly regulated over-the-counter brands. Show full articles without "Continue Reading" button for {0} hours. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. It is not known if Nexletol is safe and effective in children under 18 years of age. are pregnant. Before you start taking Nexletol, tell your healthcare provider about all your medical conditions, including if you: Nexletol may affect the way other medicines work, and other medicines may affect how Nexletol works. You may take Nexletol with or without food. Statins, which are now generic and inexpensive, are usually the best way to lower cholesterol if you need a medication. Last updated on Feb 29, 2020. Distributed by Tribune Content Agency, LLC. These are not all the possible side effects of Nexletol. tablet coating: partially hydrolyzed polyvinyl alcohol, polyethylene glycol, talc, and titanium dioxide. Lowering cholesterol is one of the most important things that can be done to decrease the risk of developing coronary artery disease. In this case, a special kind of fish oil called Vascepa will further lower your risk. Almost half of people prescribed a statin will stop in the first year of use. NEXLETOL is a tablet used once daily, in addition to low cholesterol diet and the highest dose of a statin (another drug commonly used to lower cholesterol) that a patient can tolerate. You and your healthcare provider will decide if you should take Nexletol while you are pregnant. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Take Nexletol exactly as your healthcare provider tells you to take it. Nexletol is a prescription medicine used along with diet and other lipid-lowering medicines in the treatment of adults with: It is not known if Nexletol can decrease problems from high cholesterol, such as heart attacks, stroke, death, or other heart problems.It is not known if Nexletol is safe and effective in people with severe kidney problems including people with end-stage kidney disease who are on dialysis. You may report side effects to FDA at 1-800-FDA-1088. 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