The equilibrium constant for the dissolution of a sparingly soluble salt is the solubility product (K sp) of the salt. A solubility equilibrium exists when a chemical compound in the solid state is in chemical equilibrium with a solution containing the compound. Equilibrium and non-equilibrium in solubility systems An expression such as [Ag + ] 2 [CrO 4 2– ] in known generally as an ion product — this one being the ion product for silver chromate. Determination of equilibrium solubility of a drug: The drug is dispersed in a solvent. The solubility product constant (K sp) is the equilibrium constant for a solid that dissolves in an aqueous solution.All of the rules for determining equilibrium constants continue to apply. The experimental conditions that affect equilibrium solubility values measured by the classical saturation shake-flask method have been examined, using hydrochlorothiazide as a model compound. In this study, the chasing equilibrium solubility (CheqSol) method, which has been an approved technique for many years [9-11], was used to measure the intrinsic solubility and compare the equilibrium solubility at a designated pH, which was measured using the shake-flask method. The ability to accurately measure the aqueous solubility of a material is affected by the physico-chemical properties of the material (e.g., surface area, particle size, crystal form), the properties of the solvent (e.g., pH, polarity, surface tension, added surfactants, co-solvents, salts), and the control of the solubility measurement parameters (e.g., temperature, time, agitation method). Materials and Methods. Solvents taken: First, write the BALANCED REACTION: Next, set up the SOLUBILITY PRODUCT EQUILIBRIUM EXPRESSION: It is given in the problem that the solubility of AgCl is 1.3 x 10-5. Chemicals and materials A solubility equilibrium exists when a chemical compound in the solid state is in chemical equilibrium with a solution of that compound. Samples of the suspension are withdrawn as a function of time, clarified by centrifugation,and assayed to establish a plateau concentration. Definitions. An ion product can in principle have any positive value, depending on the concentrations of the ions involved. An equilibrium constant is the ratio of the concentration of the products of a reaction divided by the concentration of the reactants once the reaction has reached equilibrium. 2) The solubility of AgCl in pure water is 1.3 x 10-5 M. Calculate the value of K sp. This type of equilibrium is an example of dynamic equilibrium in that some individual molecules migrate between the solid and solution phases such that the rates of dissolution and precipitation are equal to one another. The equilibrium is an example of dynamic equilibrium in that some individual molecules migrate between the solid and solution phases such that the rates of dissolution and precipitation are equal to one another. The suspension is agitated at a steady temperature. Because the concentration of a pure solid such as Ca 3 (PO 4) 2 is a constant, it does not appear explicitly in the equilibrium constant expression. Definitions. Determination of equilibrium solubility of a drug.

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